Ethyl Pyruvate Inhibits Hypoxic Pulmonary Vasoconstriction and Attenuates Pulmonary Artery Cytokine Expression
نویسندگان
چکیده
منابع مشابه
Hypoxic pulmonary vasoconstriction and pulmonary artery tissue cytokine expression are mediated by protein kinase C.
Pulmonary arteries exhibit a marked vasoconstriction when exposed to hypoxic conditions. Although this may be an adaptive response to match lung ventilation with perfusion, the potential consequences of sustained pulmonary vasoconstriction include pulmonary hypertension and right heart failure. Concomitant production of proinflammatory mediators during hypoxia may exacerbate acute increases in ...
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Humans encounter hypoxia throughout their lives. This occurs by destiny in utero, through disease, and by desire, in our quest for altitude. Hypoxic pulmonary vasoconstriction (HPV) is a widely conserved, homeostatic, vasomotor response of resistance pulmonary arteries to alveolar hypoxia. HPV mediates ventilation-perfusion matching and, by reducing shunt fraction, optimizes systemic Po(2). HPV...
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Hypoxic pulmonary vasoconstriction is a local reflex in the lung that diverts blood away from poorly oxygenated regions. Improvements in understanding of modulators of this response have led to pharmacologic methods whereby V/Q matching may potentially be improved in certain types of pulmonary pathology and during anesthesia for thoracic surgical procedures.
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Sex differences exist in a variety of cardiovascular disorders. Sex hormones have been shown to mediate pulmonary artery (PA) vasodilation. However, the effects of fluctuations in physiological sex hormone levels due to sex and menstrual cycle on PA vasoreactivity have not been clearly established yet. We hypothesized that sex and menstrual cycle affect PA vasoconstriction under both normoxic a...
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ژورنال
عنوان ژورنال: Journal of Surgical Research
سال: 2008
ISSN: 0022-4804
DOI: 10.1016/j.jss.2007.03.067